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Content Rheum

Interleukin-17 Inhibition

FAQs

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Describe the IL17-Induced inflammatory cascade.

Provide immunologic rationale for IL17-directed therapy in PsA, AS, and nr-axSpA.

How do you explain the timing of ixekizumab's clinical efficacy to patients?

Are IL-17 inhibitors efficacious in treating the nail-DIP complex in PsA?

Can you recapture response to IL-17i therapy after an interruption or discontinuation in therapy?

How does obesity impact the immune system?

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MEDICATION REVIEWS

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Describe the mechanism of action of ixekizumab.

What is the safety profile of ixekizumab in PsA and axSpA?

What is the efficacy of ixekizumab across the GRAPPA & EULAR domains?

JOURNAL CLUBS

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Safety of ixekizumab with or without methotrexate in biologic-naïve patients with psoriatic arthritis: 52-week results from SPIRIT-H2H study.

A head-to-head comparison of ixekizumab vs. guselkumab in patients with moderate-to-severe plaque psoriasis: 12-week efficacy, safety and speed of response from a randomized, double-blinded trial.

PODCASTS

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RhAPPcast: Navigating the Complexities: IL-17 inhibitors and IBD risk

RhAPPcast: Decoding IL-17: Comparing and contrasting IL-17A and IL-17F inhibition

Become a RhAPP Member

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