Content Rheum
Interleukin-23 Inhibition

FAQs
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Define, compare, and contrast humoral and cell-mediated immunity
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What is the role of the IL23/IL17 axis in rheumatic disease?
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Provide Immunologic Rationale For IL23 Directed Therapy in PsA, PsO, and IBD.
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Why is Binding CD64+ Important When Discussing IL23 Directed Therapy
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How does axial PsA differ from AS clinically, genetically, and radiographically
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How do you interpret radiographic progression using modified-vdHS or mTSS?
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How does real-world evidence differ from randomized controlled trials?
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How Do You Interpret cDAPSA/DAPSA and MDA?
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How Do IL-23 and IL-17 Inhibitors Differ In Clinical Efficacy?

MEDICATION REVIEWS
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Describe the mechanism of action of guselkumab
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What is Non-Responder Imputation and How is it Utilized in Clinical Trials
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How is Guselkumab dosed in PsO, PsA, and IBD
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What is the safety profile of guselkumab in PsO and PsA?
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What is the efficacy of guselkumab across the GRAPPA domains?
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JOURNAL CLUBS
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Differentiation of Therapeutic Antibodies Targeting Interleukin (IL)-23
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Long-Term Guselkumab Safety in Psoriasis & PsA (Phase II/III Analysis)

PODCASTS
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The IL23/IL17 Cascade and Implications in the Pathogenesis of PsA, PsO, and IBD
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CD64+ Binding: Description, Relevance, and Potential Clinical Implications
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The Clinical Utility of Guselkumab in Axial PsA
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The Relative Persistency and Effectiveness of Guselkumab in the Real-World
